This study examined the relationship between career barriers (low perceived social status [PSS], experiences with personal and systemic classism, and general ethnic discrimination) and college outcome expectations (COEs) among a sample of 121 Native American postsecondary students. Self-efficacy for coping with career barriers was tested as a mediator of these relationships. Results indicated that lower PSS and more experiences with both personal and systemic classism related to lower COEs, and that coping efficacy for career barriers fully mediated these relationships. Contrary to expectations, experiences with ethnic discrimination was unrelated to COEs. Implications for future research and career counseling with Native American students are discussed. (Contains 2 tables and 2 notes.)