Children may be biased toward accepting information as true, but the fact remains that children are exposed to misinformation from many sources, and mastering the intricacies of doubt is necessary. The current article examines this issue, focusing on understanding developmental changes and consistencies in children's ability to take a critical stance toward information. Research reviewed includes studies of children's ability to detect ignorance, inaccuracy, incompetence, deception, and distortion. Particular emphasis is placed on what this research indicates about how children are reasoning about when to trust and when to doubt. The remainder of the article proposes a framework to evaluate preexisting research and encourage further research, closing with a discussion of several other overarching questions that should be considered to develop a model to explain developmental, individual, and situational differences in children's ability to evaluate information.