This paper explores the role of various social ties in building trust and providing opportunities for information acquisition and knowledge exchange (IAKE). Social capital is used as a vehicle to explore the relationships between farmers and their advisors using bovine tuberculosis (bTB), a major disease facing the English cattle industry, as a case study. Much research on social capital and IAKE has been conducted within the field of rural sociology, but very little relates specifically to bTB. Exploratory findings suggest that trust provides an essential catalyst enabling passive information to be transformed into usable knowledge. Levels of "linking" social capital between farmers and the government were found to be low, engendered by high levels of distrust and a lack of confidence in the information provided. In comparison, high levels of "bridging" social capital between farmers and vets were found, brought about by long-term, regular and consistent contact, associated with high levels of trust and knowledge transfer. "Bonding" social capital was also important in encouraging knowledge exchange among farmers, although overly close ties were shown to potentially lead to the emergence of exclusive networks and, consequently, the development of distrust. The implications for bTB policy and further research are discussed. (Contains 2 tables and 2 figures.)