Online environments increasingly are becoming a part of our schools. While online education holds tremendous promise--offering viable and attractive options for advancing student skills, increasing access, and potentially lowering the cost of educational services--there is little research on the efficacy of online instruction for students with disabilities. A comprehensive review of the literature was conducted to determine if the existing literature can provide a research base for delivering evidence-based practices mediated through synchronous or asynchronous online technology for students with disabilities. (Contains 2 tables.)