The flow of international students crossing borders to pursue educational opportunities has been significantly affected by the COVID-19 pandemic, causing higher education systems worldwide to consider the context and realities of global academic mobility before and after the health crisis. In this chapter, the authors will use primary data on international educational exchange to understand the effects of COVID-19 on internationalization in US higher education. This chapter analyzes international student mobility trends before and during the COVID-19 pandemic, drawing upon comprehensive evidence reported by thousands of US higher education institutions. The chapter then discusses how COVID-19 affected international student mobility to and from US higher education institutions, including supports provided to students and flexibility regarding virtual enrollment. It concludes with a synthesis of the immediate and possible long-term effects on global student mobility patterns. [For the complete volume, "Internationalization and Imprints of the Pandemic on Higher Education Worldwide. International Perspectives on Education and Society. Volume 44," see ED674996.]