Vocabulary plays an important role in learning English. However, due to the difference between English and their mother tongue, many students find it difficult to remember the English vocabulary. This research aims at investigating whether Spelling Bee Game has any significant effects on EFL young students' vocabulary learning. The research followed a quasi-experimental design with the participation of 25 EFL grade-three learners in a primary school in the Mekong Delta. Three research instruments namely a vocabulary screening, a vocabulary test, and a semi-structured interview. The findings from the tests showed that there was a huge change between students' pre-test and post-test scores. It means students significantly improved their vocabulary before and after the treatment. Besides, most of the participants held positive attitudes toward learning vocabulary with Spelling Bee Game. The participants claimed that the use of Spelling Bee Game helps them to improve their vocabulary, increase their spelling, and pronunciation skills, helps them learn vocabulary in a fun and interesting way, and increase their self-confidence as well. The researcher suggests that further studies should consider a larger sample size to obtain a better picture of the reality of the effect of Spelling Bee Game on vocabulary learning. [For the complete proceedings, see ED672804.]