This practice guide is a revision of the updated version of "Supporting and Responding to Behavior: Evidence-Based Classroom Strategies for Teachers" that replaces, rather than supplements, the first version. The updated "Supporting and Responding (Version 2)" guide includes: (1) an expanded focus on support for students' social, emotional, and behavioral (SEB) growth; mental health; and wellbeing; (2) additional practice areas (e.g., establishing positive connections, planning relevant instruction, fostering positive relationships); (3) updated recommendations and resources that explicitly consider all student groups, including historically underserved groups (e.g., students from culturally and linguistically diverse backgrounds, students with disabilities); (4) a stronger link to targeted and individualized SEB supports; (5) an enhanced focus on staff implementation (e.g., an action planning tool, resources to monitor fidelity and access training, coaching, and feedback); and (6) updated resource links and references to empirical support.