This protocol guides the review of research that informs the What Works Clearinghouse (WWC) practice guide in the topic area of Effective Advising for Postsecondary Students. The review protocol is used in conjunction with the "WWC Procedures Handbook" and the "WWC Standards Handbook (versions 4.0)." The purpose of the "Effective Advising for Postsecondary Students Practice Guide" is to make recommendations that inform best advising practice that helps postsecondary students persist and ultimately graduate at higher rates. These recommendations will be supported by evidence from rigorous research.