This review-specific protocol guides the review of research that informs the What Works Clearinghouse (WWC) intervention reports in the Students With a Specific Learning Disability topic area. The review-specific protocol is used in conjunction with the "WWC Procedures and Standards Handbook (version 3.0)." This review focuses on interventions designed for use in a school-based setting with students in grades K-12 (generally aged 5-18) with a learning disability. The review examines the effect of interventions on the following types of outcomes: academic, problem behaviors, school engagement, self-determination, and social-emotional competence. Interventions must be implemented in authentic education settings. The following research questions guide this review: (1) which interventions are effective at improving outcomes for students with learning disabilities? Are some interventions more effective than others for students with specific learning disabilities?; (2) does the effectiveness of interventions for students with learning disabilities vary by type of outcome?; and (3) are some interventions more effective for particular subgroups of students with learning disabilities (for example, differences based on age groups, English learner status, gender, race/ethnicity, socioeconomic status, and school level) or in particular settings?