This review protocol guides the review of research that informs the What Works Clearinghouse (WWC) "Assisting Students Struggling with Reading: Intervention in Grade 4-9" practice guide. The review protocol is aligned with the "WWC Procedures and Standards Handbooks Version 4.0." As struggling readers move up the grades, they continue to experience difficulties with fluent word, sentence, and paragraph reading; academic vocabulary; and/or comprehension, which in turn severely impact their access to informational and narrative text across content areas. Providing recommendations on evidence-based practices for effective reading intervention for students in grades 4-9 seems equally important as for students in grades K-3. This practice guide addresses the need to provide evidence-based practices about interventions and supports for struggling readers in grades 4-9.