This review-specific protocol guides the review of research that informs the What Works Clearinghouse (WWC) practice guide "Using Technology to Support Postsecondary Student Learning." The review-specific protocol is used in conjunction with the "WWC Procedures and Standards Handbook (version 3.0)." This practice guide is geared toward faculty, instructional designers, and other professional staff who provide or support learning technology and instruction in postsecondary settings, and is intended to inform how technology can support effective pedagogical practice. Evidence-based recommendations are made that support the thoughtful integration of technology into postsecondary instructional settings, including classrooms, online courses, and blended (or hybrid) courses.