AI advancements are likely to have a profound impact on all aspects of society and every sector of the economy in the coming years, with changes already well underway. In this context, postsecondary institutions have a dual role: (1) to strategically leverage AI to help catalyze greater access and success into postsecondary education for all students, especially thosefrom historically underserved groups; and (2) to prepare postsecondary students for the evolving career landscape shaped by AI-driven innovation. This brief, building on the Department'searlier publication, "Artificial Intelligence and the Future of Teaching and Learning: Insights and Recommendations," provides guidance for education leaders on implementing AI applications in postsecondary settings. The brief is divided into two major sections. The firstprovides concrete recommendations, guiding questions for leadership and faculty, and resources to help postsecondary education institutions enhance learning outcomes, improve institutional operations, and prepare students for a future that is increasingly defined by fast-paced technological change. The second section is an addendum presenting evidence-based insights on AI integration. This non-exhaustive literature review examines AI's potential impact on functions such as learning environments, career readiness, admissions, enrollment, student advising, student support, digital infrastructure, and faculty development. The brief presents a broad vision of AI technologies and capabilities, based on the recommendations and a literature review, offering evidence-based insights to help institutional leaders addresspolicy issues and leverage AI in ways that support holistic student development and success.