This study examined the relationship of pre-service teachers' personality factors, dispositions, grit, self-efficacy, and commitment by exploring the interplay of these relationships and their potential predictive nature. Teacher retention is a pressing issue, as 42% of new teachers are likely to quit the profession within five years of entry (Ingersoll et al., 2014). Previous literature has posited that understanding the psychological profiles of pre-service teachers could provide an avenue to better prepare teachers and may have the potential to attract, assist, and retain quality teachers (Corcoran & O'Flaherty, 2016). An online set of instruments composed of a demographic questionnaire and five self-report measures was completed by 145 pre-service teachers. Results were analyzed using bivariate correlations and stepwise regression. Many statistically significant relationships were found. Dispositions and grit significantly predicted self-efficacy. Grit, neuroticism, dispositions, and agreeableness significantly predicted commitment. Conscientiousness and neuroticism significantly predicted grit. Conscientiousness, agreeableness, and extraversion significantly predicted dispositions. This study provided evidence that significant relationships exist among several psychological characteristics of pre-service teachers. Multiple factors appear to display an interaction effect indicating pre-service teachers' demonstrating psychological strengths in one area may likely possess strengths in other areas. Pre-service teachers may draw upon these psychological assets when faced with challenges. The results suggest the inverse may also be true. Pre-service teachers displaying lower levels of psychological assets may be prone to experiencing psychological distress across other factors and may benefit from additional external supports such as mentoring. This information can help teacher preparation programs consider specific interventions to target these factors to better prepare pre-service teachers. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com.bibliotheek.ehb.be/en-US/products/dissertations/individuals.shtml.]