This dissertation is concentrated on transgender students with recognition of LGBTQIA+ students across the board. There is a deficiency of information in education on how to assist high school students who are transgender. This literature review encompasses the transgender experiences and addresses major depression, gender dysphoria, minority stress, and suicide, which is highest among cisgender peers in the United States. Bullying, victimization, harassment, and not being able to utilize restrooms according to a student's gender identity are just some of the issues transgender students experience. Inclusive school policies are required to establish equity throughout high schools. School educators need to know the risk factors to assist in treatment and program development to provide transgender students with better opportunities to succeed. The protective factors to help promote resiliency among transgender students are essential for school educators to recognize. It is important for the educational system to bring higher awareness to this population and educating parents, students, and the overall community of the stigma embedded within the transgender population. If transgender issues are not addressed, the population increases the probability of negative consequences that could last through adulthood with negative self-esteem, mental health issues, eating disorders, and substance abuse. Through Bronfenbrenner's ecological system, school educators can gain the knowledge that is necessary to understand transgender and gender nonconforming students through the microsystem, the mesosystem, the exosystem, and the macrosystem. Training all key stakeholders is necessary to establish a safe environment for transgender and gender nonconforming high school students. Knowing how to redirect school staff and peer harassment by learning pronouns, affirming gender identity by using their preferred name, and advocating for inclusive curriculum is a promising step toward equity. Examining all these areas of mental health of transgender and gender nonconforming students needs to be assessed by all school educators, particularly school psychologists who are in a unique position to develop services to assist with mental health issues that the transgender population endures. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com.bibliotheek.ehb.be/en-US/products/dissertations/individuals.shtml.]