The purpose of the study was to determine whether self-care mediates the relationship between stress and burnout in school counselors, as well as to learn the relationship among the three variables. There are multiple stressors associated with the role of school counselor. In school counselors with low coping resources, such stress may lead to burnout. Burnout reduces the ability of school counselors to effectively perform their duties. Past research has primarily focused on external sources of stress; yet it is possible that if school counselors engage in self-care, it could increase their capacity to cope and reduce the likelihood of developing burnout. The study used a quantitative research design in which correlational and mediational analyses were performed. The three variables that were studied were self-care, stress, and burnout. The population used in the study were school counselors who work full time across the U.S. who were over the age of 18. The selection of participants was conducted using nonprobability sampling. The sample was diverse in terms of ethnically and location of school. Nearly two thirds were African American and nearly one third White, which approximately reflected the client population. Data were analyzed using the SPSS version 27 for windows. All statistical tests were two-sided ([alpha] = 0.05), with statistical significance established at 0.05. The findings showed that the three variables of stress, burnout, and self-care were highly correlated to one another but that self-care did not mediate the relationship between stress and burnout. Those who were younger, had less years of experience, and worked in the inner city reported less stress, burnout, and higher engagement in self-care practices. Most participants practiced physical self-care. Self-care did reduce the stress on burnout but not significantly. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com.bibliotheek.ehb.be/en-US/products/dissertations/individuals.shtml.]