Like all teens, students with autism spectrum disorder (ASD) go through puberty. During this transitional time, their bodies will go through changes that can be disorienting. Given that adolescents with ASD may have a need for sameness and routine, the changes associated with puberty can be difficult. Teachers and parents can support students by educating the teens in advance about the changes related to puberty and by giving clear guidelines about appropriate health and social behaviors during the transition to adulthood. "Autism at-a-Glance" is a series of practitioner and family-friendly documents created by the Center on Secondary Education for Students with ASD (CSESA) designed for high school staff members supporting students on the autism spectrum, as well as family members of adolescents with ASD. This "Autism at-a-Glance" was designed to support high school staff and family members in supporting adolescents on the autism spectrum during the changes associated with puberty.