The COVID-19 pandemic has had major impacts on child care and early education (CCEE) in the U.S. This report describes calendar year 2020 experiences of CCEE centers that were operating in 2019, including changes in their enrollments and their instructional staff. It also describes the extent to which centers received pandemic assistance during that time, and the associations between receipt of pandemic assistance and center closures. The authors use data from the 2019 National Survey of Early Care and Education (NSECE) Center-based Provider Survey and the first wave of the NSECE COVID-19 Longitudinal Follow-up Center-based Provider Survey. The respondents in the NSECE COVID-19 Longitudinal Follow-up Center-based Provider Survey are representative of centers that were open in 2019, and who are reporting on the experiences of those centers during 2020. In this report the authors discuss centers that were serving children in 2019, comparing their characteristics at two time points: 2019 (before the COVID-19 pandemic) and October 2020 (seven months after the onset of the pandemic).