Despite the significant contributions of graduate students and postdoctoral scholars to scientific research, the environments in which they work and learn often offer inconsistent mentorship and professional development opportunities and only intermittently address their mental, financial, and social well-being. To examine mentorship, well-being, and professional development and the challenge of translating existing mentorship theory into effective interventions, The Roundtable on Mentorship, Well-being, and Professional Development convened a workshop on November 1 and 2, 2023. This publication summarizes the presentation and discussion of the workshop.