Objective: This study explores whether variability in the implementation of an undergraduate course on human flourishing is differentially associated with student outcomes. Participants: 101 students in the "Art and Science of Human Flourishing" across three large, public, R1 universities in Fall 2018 participated in the study. Methods: Formative course data included researcher observations of weekly class pedagogy, students' weekly meditation practice logs and end-of-course assessments, and pre/post surveys measuring changes in participating students' outcomes related to flourishing (e.g., attentional skills, social-emotional skills, perspectives on flourishing, mental and physical health). Results: Although course pedagogy and student engagement varied across the three universities, students' outcomes were nonetheless similar. Conclusions: Variability in course implementation did not appear to differentially affect students' outcomes. We tentatively conclude that other institutions interested in offering the flourishing course may make limited adaptations to fit their pedagogical preferences without concern for altering its impact on students. [This paper was published in "Journal of American College Health" v71 n4 p1111-1124 2023.]