Today and in the future, a growing array of Artificial Intelligence (AI) models and capabilities will be incorporated into the products that specifically serve educational settings. The U.S. Department of Education (Department) is committed to encouraging innovative advances in educational technology (edtech) to improve teaching and learning across the nation's education systems and to supporting developers as they create products and services using AI for the educational market. Building on the Department's prior report, "Artificial Intelligence and the Future of Teaching and Learning: Insights and Recommendations" (2023 AI Report), this guide seeks to inform product leads and their teams of innovators, designers, developers, customer-facing staff, and legal teams as they work toward safety, security, and trust while creating AI products and services for use in education. This guide addresses not only developers of products for formal education settings--including elementary and secondary schools, colleges, and universities--but also for educational uses at home, community, and other informal settings. Each section of this document is built around a core recommendation and includes a set of discussion questions that leaders in organizations can use to foster conversation, next steps to promote robust development processes, and resources that can provide additional support. Developers can use this guide to increase their understanding of essential federal guidelines and guardrails to guide their work as they create AI applications for educational settings.