The Commonwealth of the Northern Mariana Islands Public School System requested a systematic review of Tier 2 literacy interventions for students in grades K-3. This review defines a Tier 2 literacy intervention as a supplemental instructional program for students who require support in addition to the Tier 1 core reading program. Of the 267 studies on Tier 2 literacy interventions identified, 20 met What Works Clearinghouse 5.0 standards with or without reservations. Two interventions--Reading Recovery and Literacy First--had strong evidence of positive effects (as defined by the Every Student Succeeds Act) on students' literacy skills. One additional intervention--Achieve3000--had moderate evidence of positive effects. This report includes an evidence and gap map and a supplemental matrix that highlights implementation strategies used in each intervention.