In this research brief, SRI presents six lessons about equitable scaling from a retrospective study of the Deeper Learning + Diffusion of Innovation and Scaled Impact Initiative (DL+D initiative). Funded by the William and Flora Hewlett Foundation beginning in 2018, the goal of the DL+D initiative was to generate knowledge about how fundamental shifts to teaching and learning could be scaled within public school systems efficiently, expediently, and equitably. The Hewlett Foundation funded 10 research-practice partnerships, collaborations that are intentionally organized to leverage diverse expertise to accelerate educational improvement or equitable transformation through engagement with research. The lessons presented in this research brief are informed by both the challenges and the successes that the 10 RPPs experienced and are broadly useful for any school district or funder interested in catalyzing complex instructional improvement at scale and with attention to equity.