Data harmonization is an emerging approach to strategically combining data from multiple independent studies, enabling addressing new research questions that are not answerable by a single contributing study. A fundamental psychometric challenge for data harmonization is to create commensurate measures for the constructs of interest across studies. In this study, we focus on a regularized explanatory multidimensional item response theory model (re-MIRT) for establishing measurement equivalence across instruments and studies, where regularization enables the detection of items that violate measurement invariance, also known as differential item functioning (DIF). Because the MIRT model is computationally demanding, we leverage the recently developed Gaussian Variational Expectation-Maximization (GVEM) algorithm to speed up the computation. In particular, the GVEM algorithm is extended to a more complicated and improved multi-group version with categorical covariates and Lasso penalty for re-MIRT, namely, the importance weighted GVEM with one additional maximization step (IW-GVEMM). This study aims to provide empirical evidence to support feasible uses of IW-GVEMM for re-MIRT DIF detection, providing a useful tool for integrative data analysis. Our results show that IW-GVEMM accurately estimates the model, detects DIF items, and finds a more reasonable number of DIF items in a real world dataset. The proposed method has been integrated into R package VEMIRT (\url{https://map-lab-uw.github.io/VEMIRT}). [This paper will be published in "Psychometrika."]