The study tried to ascertain the impact of instructors' credentials and professional expertise on students' biology achievement in Birim Central Municipality, Eastern Region, Ghana. The study used survey design. The respondents were chosen using simple and selective probability sampling. 80 biology teachers and four head teachers gave us the 84-sample size. A questionnaire served as the main research tool, and the data analysis was accomplished with the help of the Statistical Package for Social Sciences (SPSS). Many respondents (60.7%) firmly agreed that teachers who possess superior knowledge and skills are better able to instruct students. Majority of those surveyed strongly agreed that experienced teachers are more understanding whenever it involves dealing with behavioral issues of children. This study was intended to considerably add to knowledge in order to enhance students' biology performance and comprehension. [For the full proceedings, see ED654100.]