Before nursing graduates can practice as a registered nurse, they must successfully pass the National Council Licensure Examination for Registered Nurses (NCLEX-RN). Low first-time pass rates on this high-stakes test can cause concern for multiple stakeholders including graduate nurses, nursing programs, health care organizations, and society. The purpose of this study was to evaluate the relationship between content-specific standardized assessments and NCLEX-RN outcomes. Student percentage scores from three content-specific standardized assessments (adult medical surgical, leadership and management, and pharmacology) were used as predictor variables to evaluate if there was a relationship to the dichotomous first attempt outcome (pass or fail) on the NCLEX-RN. The three selected assessments were developed by Assessment Technologies Institute (ATI). The records of 256 graduates from an associate degree nursing program were analyzed utilizing archival, secondary data, and regression analysis. Utilizing binomial logistic regression with an ? level (p-value) of 0.05, findings revealed that the ATI adult medical surgical assessment percentage score was a statistically significant predictor of NCLEX-RN outcomes. The ATI leadership and management and pharmacology assessments were not statistically significant predictors of NCLEX-RN outcomes. The overall regression model correctly predicted 94.9% of the cases. This study adds to the nursing education literature and may be used as a foundation for further research to identify variables that may affect first attempt outcomes on the NCLEX-RN. Determining which variables predict success on this high-stakes licensure examination may assist nurse educators, administrators, and researchers with making decisions on how to facilitate student learning, conduct program evaluation, institute curricular improvements, and address the nursing shortage. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com.bibliotheek.ehb.be/en-US/products/dissertations/individuals.shtml.]