Adolescence is a period of growth, independence, and exploration, with increased curiosity and risk-taking behaviors (Centers for Disease Control and Prevention [CDC], 2021b). Evidence has shown an increase in mental health concerns during adolescence, including suicidal behaviors (CDC, 2023b; Plemmons et al., 2018; Yard et al., 2021), as well as substance use such as cannabis (CDC, 2021c). Cannabis is one of the most commonly used substances in the United States, with four in ten high school students using cannabis at some point during their lifetime (CDC, 2021c). This study examined data from a voluntary national school-based survey, the "Youth Risk Behavioral Surveillance - System" (YRBS). The sample included 17,232 high school adolescents, and a chi-square test for association analysis was used to explore associations between categories within the YRBS. Results indicated a significant relationship between cannabis use, mental health concerns, and suicidal thoughts and behaviors in adolescents. This study informs the impact of cannabis use on adolescents and highlights areas of growth to support adolescents better, specifically, adolescents using cannabis as a coping tool and struggling with use. Given how common cannabis use is among adolescents, school psychologists will gain valuable knowledge on how to educate school staff, families, and students on the impact of cannabis. School psychologists will be able to contribute to more effective prevention programming that supports adolescents exploring and struggling with cannabis use. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com.bibliotheek.ehb.be/en-US/products/dissertations/individuals.shtml.]