In 2010 the American Management Association Critical Skills Survey found that three out of four (75.7 percent) executives believed 21st Century Skills would become more important to organizations as the economy grew toward a global marketplace. The problem to be addressed was how high school teachers in the Midwest were integrating 21st Century Skills into classroom curricula that is designed to ensure local high school students are prepared for the global workforce upon graduation. That problem, specifically, was the failure of high school students to effectively demonstrate the use of 21st Century Skills upon graduation when applying for college or entering the workforce. The purpose of this qualitative case study was to explore how high school teachers in the Midwest were integrating 21st Century Skills into classroom curricula that is designed to ensure local high school students are prepared for the global workforce upon graduation. A qualitative methodology and case study were applied to explore answers to questions related to "why" and "how" a phenomenon occurs. The Partnership for 21st Century Skills Framework was used to correlate skills teachers should integrate into the classroom to prepare graduates for global environments of the future. Data was collected through open-ended interview questions, field notes, and teacher-generated lesson plans to establish themes that corresponded with research questions. Key findings of this study confirmed that participants integrated some elements of 21st Century Skills into the curriculum; however, there is still progress to be made in preparing high school graduates to compete in a 21st century global environment. A future recommendation would be to recreate this qualitative study using a larger sample size to draw valid conclusions and reduce bias. A larger sample size could potentially result in more accurate values that eliminate outliers, skewing of data found in small sample sizes, and reduce the error margin. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com.bibliotheek.ehb.be/en-US/products/dissertations/individuals.shtml.]