The purpose of this study was to understand the perception of self-efficacy and training of teachers to teach high school students with disabilities in the regular education classroom in rural schools in Missouri. The theoretical framework for this study was Bandura's (1977) theory of self-efficacy. The participants in this study were high school principals and high school general education teachers in rural public school districts in the state of Missouri. This study included themes of teacher experience, special education leadership, collaborating with special education teachers, and professional development. This study reviewed how teacher experience and professional development impact a teacher's self-efficacy in the regular education classroom. This study discussed the importance of collaboration with special education administration, special education teachers, and regular education teachers. The personal experiences of how behavior difficulties are handled in the regular education classroom or the lack of behaviors was noted from the teachers within the study. This study provided information on the need for training for general education teachers in the area of research-based strategies and the use of assessments for students with disabilities in the regular education classroom. Administrators should provide opportunities for general education teachers to gain experiences in working with students with disabilities in the regular education classroom. School districts should focus on professional development to increase teacher confidence to teach students with disabilities and provide professional development training on inclusion and working with students with disabilities in an inclusive setting. Time should be provided for general education teachers to collaborate with special education teachers to increase the self-efficacy of regular education teachers to teach students with disabilities in the regular education classroom. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com.bibliotheek.ehb.be/en-US/products/dissertations/individuals.shtml.]