This study was designed to determine the effectiveness of a computer assisted instruction to deliver discrete trial training of academic skills to students with significant intellectual disabilities. Based upon the principles of Applied Behavioral Analysis, discrete trial training was identified as an evidence-based practice in teaching skills to students with disabilities. The criteria for single-subject case research within a multiple baseline design across behaviors and participants was implemented for this study. The individual subject and the repeated measures across skills served as the experimental control to verify results. The multiple baseline design evaluated the effect of the intervention computer assisted instruction to deliver discrete trial training to teach early literacy skills to students with significant disabilities. Results of the study indicated the use of computer assisted instruction in the delivery of discrete trial training is effective in teaching individuals with significant intellectual disabilities early literacy skills. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com.bibliotheek.ehb.be/en-US/products/dissertations/individuals.shtml.]