The use of substance has risen in America over the years so much so that the last few years America has been battling an opioid crisis. The age of reported first use of substances has been as early as 10 years of age. Many prevention programs have developed over the years to reduce the risk of substance use and misuse, and later addiction. Few programs are tailored towards addressing the morbidity of mental illness and substance use disorders especially neurodevelopmental disorders, which have been shown to be highly correlated with substance use. The Assessing Substance Use Risk and Effective Prevention Strategies for Neurodevelopmentally Comprised Teens training module was developed specifically for special educators with the goal of increasing special educator's ability to assess substance use risk in adolescents and teenagers and implement prevention strategies that would reduce the risk of substance use. The purpose of this study was to examine the effectiveness of the training module in increasing special educators' ability in assessing substance use risk in teenager and to implement prevention strategies. The study compared the pre-test and post-test and the results of this study found that pre-test was positively correlated with the post-test. Results also found a positive correlation between the post-test and participant review. The results suggest that the training module may have an effect on increasing special educators' ability to assess risks of substance use and implement prevention strategies although further research involving a control group should be conducted to determine this effect. The clinical implications of these findings, along with limitations and recommendations for future research, are reviewed. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com.bibliotheek.ehb.be/en-US/products/dissertations/individuals.shtml.]