This qualitative exploratory case study looked at the challenges of perceived accessibility that needed to be addressed for visually impaired students to succeed in degree completion within the online learning environment. The biopsychosocial model of disability examined how human and environmental factors (social, biological, and psychological) affected this student population's overall accessibility and successful degree completion. Recent studies have documented that visually impaired students in higher education often encounter barriers, resulting in academic failure or withdrawal from their studies. Semi-structured, virtual Zoom interviews were the data collection instruments of the study. Ten visually impaired college students enrolled in at least one online course at a two-year or four-year college/university participated in the study. This study suggested that there may be five related themes of accessibility challenges encountered in the online learning environment affecting successful degree completion for visually impaired college students: (1) incompatibility with assistive technology/websites; (2) lack of effective communication with professors; (3) problems with the accommodations process; (4) the need for disability awareness training; and (5) issues accessing online campus services. In addition, this study suggested that online college students with visual impairments felt their accessibility challenges and human and environmental factors were related to several factors. These factors include students' preferred learning styles, delivery methods of instructional design, and the students' cognitive personality styles. The results of this study might alert college and university disability services, professors, and instructional designers of the need to re-evaluate their overall policies of accessibility within the virtual classroom for students with visual impairment. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com.bibliotheek.ehb.be/en-US/products/dissertations/individuals.shtml.]