The current study addresses the problem that Ghanaian practicum student teachers are not adequately prepared in their application of instructional strategies to teach the diversity of students with multiple disabilities. The purpose of the current study is to examine Ghanaian practicum students' self-efficacy in their instructional strategies for students with multiple disabilities based on the special education program provided by the University of Cape Coast. Bandura's Theory of Self-Efficacy drove the theoretical guiding framework. The researcher collected data from a convenience sample of 143 practicum student teachers using a 5-Likert modified Teacher Self-Efficacy Scale. The Teacher Self-Efficacy Scale was used to measure practicum student-teacher efficacy in efficacy in instructional strategies, efficacy in student engagement, and efficacy in classroom management. The study used SPSS as a research tool to analyze the collected questionnaire-based data. The researcher used ordinal regression analysis to assess the efficacy levels of the relationship of predictor variables (efficacy in student engagement and efficacy in classroom management) to the dependent variable (efficacy in instructional strategies) based on the result of the TSES scale. The researcher found a statistically significant direct relationship between independent variables and the dependent variable. The results concluded the rejection of the null hypothesis in favor of the alternative hypothesis and yielded that Ghanaian practicum student teachers' engagement efficacy does correlate perfectly with the instructional strategies efficacy for students with multiple disabilities. The results also indicated a perfect correlation between Ghanaian practicum student-teachers efficacy in classroom management and their efficacy in instructional strategies for students with multiple disabilities. Future research may include a similar study design with a larger sample size. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com.bibliotheek.ehb.be/en-US/products/dissertations/individuals.shtml.]