Nursing professional development (NPD) is an evolving nursing specialty role that combines expertise in clinical nursing with ongoing education in acute care settings. A novice NPD practitioner may not understand the complexities, demands, and stressors that accompany a work role transition. This qualitative case study used thematic analysis and revealed four themes associated with the successful work role transition of an expert clinical nurse to the novice NPD practitioner. The conceptual framework guiding this study was Nicholson's work role transitions theory. The first research question sought to determine the professional experiences of expert clinical nurses as they transition into the novice NPD practitioner role. The second question, guided by Nicholson's theory, asked how the personality characteristics, self-discipline, and personal control factors influence a successful transition. Study participants were identified through a purposive sampling of 11 NPD practitioners in the United States with less than 3 years of experience in the NPD practitioner role. A qualitative data analysis was performed using a computer-assisted qualitative data analysis software. The results of this study revealed four themes: (a) no orientation to role, (b) lack of skills, (c) self-directed in role, and (d) motivation to succeed. Key elements within each theme were identified that support future successful work role transitions from expert clinical nurse to novice NPD practitioner. Further examination and implementation of these elements would be impactful on the retention of novice NPD practitioners. The findings of this study may lead to positive social change in the healthcare industry by increasing retention and increased patient satisfaction and outcomes. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com.bibliotheek.ehb.be/en-US/products/dissertations/individuals.shtml.]