Globalization's in-depth development is profoundly affecting the real world with its penetrating power and wide scope. As the main means of global participation in higher education, internationalization is bound to be affected by today's global challenges. This dissertation reports the research designed to investigate the impact of current global challenges on the internationalization of U.S. higher education. After the qualitative data analysis and the quantitative descriptive statistical analysis, the results were converged for step-by-step comparison. The final convergent data revealed that the COVID-19 pandemic, nationalism, immigration policy, technology revolution, and global competition were the current challenges impacting the internationalization of U.S. higher education. International challenges included the COVID-19 pandemic, technological revolution, and global competition, while domestic challenges included nationalism and immigration policy. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com.bibliotheek.ehb.be/en-US/products/dissertations/individuals.shtml.]