The comprehensive internationalization of higher education has long been viewed as important for student development and institutional global research engagement. The reasons for internationalization have been studied in-depth, but few studies exist linking higher education internationalization and institutional reputation, often measured through ranking systems. Grounded in internationalization literature and reputation theories from the field of organizational management, this dissertation examines the relationship between the comprehensive internationalization of higher education and the "U. S. News and World Report" college rankings reputation scores and overall rankings. Using a sample of 259 institutions that both completed the American Council on Education's "2016 Mapping of Internationalization" survey and were ranked in the USNWR college rankings in 2016, this study found that multiple significant correlations exist between internationalization and the USNWR college rankings and reputation scores. Additionally, comprehensive internationalization emerged as a predictor of both reputation scores, explaining 34% of the variance, and of ranking scores, explaining 26.4% of the variance. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com.bibliotheek.ehb.be/en-US/products/dissertations/individuals.shtml.]