In recent years, there has been a growing understanding that consistent developmental relationships support student learning and well-being. Research shows that youth who have positive connections with adults at their schools demonstrate higher levels of motivation, self-esteem, and prosocial behavior than their peers in less relationship-centered contexts. Relationship-centered schools also enable a range of positive student academic outcomes, including increased attendance, graduation rates, achievement on English language arts and math assessments, and college-going rates. Relationship-centered schools challenge ingrained structures that have come to characterize U.S. secondary schools and often inhibit their growth and sustainability through institutional, normative, and policy barriers. While research indicates that relationship-centered environments positively support student learning and success, it has been difficult to build and sustain schools with relationships at their foundation, particularly at the secondary level. This report focuses on one relationship-centered high school transformation effort--the Relationship Centered Schools (RCS) campaign, a youth-led effort supported by the community-based organization Californians for Justice (CFJ). Through interviews with CFJ organizers, district and school leaders, practitioners, and current and former youth organizers, this report highlights examples of uptake in two settings--the Long Beach Unified School District and Fresno's McLane High School. The cases demonstrate how local schools and districts have furthered relationship-centered schooling, the conditions and factors that have enabled or hindered RCS work, and the emerging impacts of RCS efforts on practice and policy.