Background: Distance education is a growing sector in higher education but continues to lag in medical imaging education. Educators continue to utilize the traditional teaching method stating technology as the major challenge to adding distance education to their curriculum. Lack of faculty development and information technology support are the biggest obstacles. The purpose of this literature review is to provide a guide of best practices for distance education in medical imaging curricula. Methodology: Peer-reviewed articles from online databases, and radiologic sciences and medical imaging society resources were selected for this literature review. Abstracts were reviewed for their relevance regarding radiologic sciences or medical imaging and distance education. Results: Results of this literature review demonstrated distance education as a replacement using the hybrid method for medical imaging curriculum. Transitioning curriculum to distance education will afford students the flexibility and convenience of online courses while supporting their clinical experience. Best practices include faculty development and student orientations to the distance education delivery method for greater success. Course development involves utilizing the numerous tools offered in a learning management system to address all learning styles and preferences. Video-based learning and virtual health care environments support students in transitioning the theoretical knowledge of medical imaging to the clinical environment. Conclusion: Utilizing the hybrid model of distance education will provide students with student-centered learning. The variety of tools and resources to support the transition to distance education in medical imaging curricula will address the diverse student population. These tools will help students acquire the skills needed to be a high-quality, entry-level medical imaging professional. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com.bibliotheek.ehb.be/en-US/products/dissertations/individuals.shtml.]