Few studies exist studying the implementation of a mindfulness program among high school students with disabilities. This study examined outcomes from the implementation of a 6-week "Learning to BREATHE" program, which is a mindfulness-based program for adolescents. This study explores behavioral problems, self-efficacy, self-regulation, mindfulness, and emotion regulation strategies from pre- to post-intervention. A single-case study, AB phase change design was used to measure how students changed over time. A total of 8 high school students in a self-contained special education classroom participated in the study. Students had classifications including autism, intellectual disability, visual impairment, and other health impairment with cognitive abilities, adaptive functioning, and academic performance below their same-aged peers. Data was collected from teacher and student rating scales, teacher interviews, and classroom observations. Although this study is unable to discuss causal relationships among variables, the study found that the students and special education teacher rated students as displaying slightly higher levels of self-regulation, slightly higher levels of mindfulness, and more access to emotion regulation strategies after the program. However, this study showed conflicting results with behavioral problems as the teacher reported fewer behavioral problems, while students reported more behavioral problems. Additionally, this study did not show improvement in students' self-efficacy. These findings add to the limited research exploring a mindfulness program among high school students in special education. Future research is needed to explore the effectiveness of tailoring lessons and measures according to the cognitive needs of students with disabilities. Additional implications for future research are discussed. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com.bibliotheek.ehb.be/en-US/products/dissertations/individuals.shtml.]