This qualitative case study explores Ghanaian graduate students' social and cultural experiences in a technology-mediated learning environment at a southwestern university. Whereas most studies predominantly focus holistically on international students' experiences in the US, and researchers give little attention to nationals from sub-Saharan Africa, institutions likely to ignore the power and the manifestation of unique cultural values within learning environments. Students' sociocultural characteristics play a pivotal role in negotiating new experiences and adjusting to technology-mediated learning environments. The study adopts the lens of Hofstede's cultural dimension framework to understand the differences Ghanian graduates take to a learning environment to interact with learning technologies and faculty members while engaging in academic activities. I interviewed seven Ghanaian graduate students for about 50 minutes using Zoom, and each participant had the freedom to compare their experience with a Ghanaian and US higher institution. I transcribed the Zoom transcripts and uploaded the data to Taguette. I used Kalpokaite and Radivojevic's (2019) foundational model of iterative cycle of data analysis to analyze the data. The findings show that Ghanaian graduate students' sociocultural practices influenced how they initially perceived Canvas (Learning Management System) and perceived their interaction with faculty members. Also, the findings reveal that the students' culture played a pivotal role in the people they associated with as they tried to seek support and adjust to new learning environments. Evidently, Ghanaian students exhibited high power distance, strong uncertainty avoidance, and collective attributes. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com.bibliotheek.ehb.be/en-US/products/dissertations/individuals.shtml.]