Research indicates that being skilled in self-determination may contribute to academic success for college students with disabilities. However, few studies investigate the self-determination levels of disabled students upon registration with the disability services office to inform practice. This quantitative research study analyzes the self-determination levels of 114 undergraduate students with disabilities who completed an in-person intake appointment with the Student Access Center at the University of Kansas. Using the Self-Determination Inventory Adult Report (SDI-AR), a new measure of self-determination based on the latest framework of self-determination, Causal Agency Theory, this study investigates the differences in self-determination based on the demographic characteristics of students, including gender, race/ethnicity, first-generation, Pell-grant eligibility, and disability. This study also explores the relationship between self-determination and student persistence between the 2021 and 2022 academic years. Using the principal scores on the SDI-AR (Overall, Decide, Act, and Believe), the results of this study indicate that while KU students with disabilities have relatively high self-determination, 20% of the sample attained at least one subscore in the bottom quartile. Furthermore, White students with disabilities have significantly higher levels of self-determination than students of Color on all SDI-AR scores. Additionally, results indicate significant differences within the Believe score across other demographic characteristics. For example, students with disabilities who are first-generation college students and Pell Grant eligible have significantly lower self-determination than non-first-generation or Pell Grant-eligible students on the Believe subscore. This difference in the Believe score was also seen in student age and disability. Finally, the results indicate no significant association between self-determination scores and persistence in the academic year 2021-2022 based on students' academic level. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com.bibliotheek.ehb.be/en-US/products/dissertations/individuals.shtml.]