Primary informal caregivers perform most of the caring work with no financial compensation and often no training, experiencing the burden of care. Unless their socioeconomic status allows them to hire a formal caregiver for their care recipients or use healthcare facilities, they need to spend their opportunity cost to take care of their care recipients. Moreover, long-term primary informal caregivers are more likely to develop physical, psychological, and socioeconomic problems that could negatively impact the well-being of their care recipients and other family members. Building and facilitating informal care networks involving multiple temporary informal caregivers (e.g., secondary caregivers, bystanders) could reduce primary informal caregivers' burdens and support the well-being of both primary informal caregivers and their care recipients. I started with two studies that identified and discussed the potential benefits of temporary care from others and information and communications technologies (ICTs) that can help primary informal caregivers effectively share their care responsibilities with others. Then, focusing on epilepsy, one of the most common neurological chronic diseases causing recurrent and unprovoked seizures, I have conducted two other studies to understand not only the needs and challenges of people with epilepsy and their caregiver but also public awareness and stigma on them. As one of the technological solutions to facilitate informal care networks for epilepsy, I designed and evaluated gamified educational content to increase public awareness targeting young students who are more likely to develop proper perceptions with early education. My dissertation contributes to Human-Computer Interaction (HCI) and Computer-Supported Cooperative Work (CSCW) research. It sheds new light on the potential of informal care networks that can increase effective and efficient care and mitigate primary informal caregivers' burdens. Finally, it can be extended and applied to provide insights into future research on understudied chronic diseases that need care and assistance from others. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com.bibliotheek.ehb.be/en-US/products/dissertations/individuals.shtml.]