The effects of the opioid crisis have been felt across the country, and many educators are seeking ways to be proactive around their students' needs. An important step toward this goal is identifying students who need support. The Center on PBIS website (PBIS.org) provides multiple resources with provide general guidance on screener selection and implementation. This practice brief is intended to provide educators with more specific, supplemental direction for substance misuse screening and a brief overview of how such screening can be combined with brief intervention and referral to treatment.