Ithaka S+R's Research Support Services program's most recent project, "Supporting Big Data Research," focused specifically on the rapidly emerging use of big data in research across disciplines and fields. As part of this study, they partnered with librarians from more than 20 colleges and universities, who then conducted over 200 interviews with faculty. These interviews provided insights into the research methodologies and support needs of researchers working across a wide range of disciplines. This report provides a detailed account of how big data research is pursued in academic contexts, focusing on identifying typical methodologies, workflows, outputs, and challenges big data researchers face. Full details and actionable recommendations for stakeholders are offered in the body of the report, which offers guidance to universities, funders, and others interested in improving institutional capacities and fostering intellectual climates to better support big data research. [Contributions to this report were made by: Thea P. Atwood, Neelam Bharti, Bryan Briones, Patrick Campbell, Paula Carey, Daniel Castillo, Karen Ciccone, Cameron Cook, Danielle Miriam Cooper, Claire Curry, Justin De La Cruz, Will Dean, E.M. Dragowsky, Tom Durkin, Darnell Epps, Seth Erickson, Jen Ferguson, Erin D. Foster, Moriana Garcia, Zenobie S. Garrett, Ann Glusker, Ben Gorham, Jen Green, Hannah Gunderman, Jacalyn Huband, Jennifer Huck, Susan Ivey, Carolyn Jackson, Kelsey Jordan, Kate Kryder, Stephanie Labou, Mark Laufersweiler, Tracie Lewis, James Macalino, Tobin Magle, David Minor, Lana Munip, Rosaline Odom, Reid Otsuji, Jennifer Patiño, Tyler Pearson, Carissa Phillips, Sara Pugachev, Brian Quigley, David Rachlin, Melanie Radik, Vicky Rampin, Fred Rowland, Laura Sare, Rebecca M. Seifried, Adam Shambaugh, Sarah Siddiqui, Kate Silfen, Iyanna Sims, Bryan Sinclair, Margaret Smith, Gretchen Sneff, Mandy Swygart-Hobaugh, Paria Tajallipour, Julia Unis, John Vickery, Cynthia Vitale, Jeremy Walker, Huajin Wang, John Watts, Christie A. Wiley, Katie Wissel, Nicholas Wolf, Cindy Xuying Xin, Jen-Chien Yu, Roger Zender, and Lee Zickel.]