Minority-Serving Institutions (MSIs) play a critical role in ensuring college access and opportunity for underserved and underrepresented students. Although MSIs encompass only a small percentage of all colleges and universities, they are disproportionately responsible for educating and preparing a large proportion of students of color, as well as all students, for their future careers. Undeniably, the strength of America's economy relies on the success of all of our students, including students of color. However, in the 21st century, a high school education no longer suffices for career and community success. College Promise programs enable hardworking and resilient students to complete a college degree or certificate, starting in America's community colleges. With this in mind, supporting Minority-Serving Institutions through College Promise programs is a logical and proactive step to increase the number of students attending college, as well as serve the large number of students and students of color who are currently attending MSIs. Thus, this research brief will discuss the potential of MSI-based College Promise programs to enhance the college access, completion, and success of America's students. [This report was published by College Promise.]