This study is to assess the perceptions of the teachers on student centered instruction for interactive and effective teaching and learning. It also focuses the importance of student centered instruction for interactive and effective learning in context of Bangladesh. In the traditional approach to teaching, most of the class time is spent with the teacher lecturing and the student watching, listening and taking notes. Most of the time students work individually on tasks and assignments, and group work or collaborative learning is hardly encouraged. Traditionally instructors focus on what they are going to do in the class, what should be the teaching method and topics; not on what the students are actually learning and interested in. This emphasis on the instructor often leads the students to remain as passive learners and students do not take responsibility for their own learning. However, through this investigation the perceptions of the teachers regarding effective and active student learning have been found and therefore few recommendations have been suggested. In the end teachers also agreed that student centered instruction will improve the ability of the students to learn the content and they have to prepare differently for the class.