This brief helps educators implementing a Multi-Tiered System of Supports (MTSS) framework, like positive behavioral interventions and supports (PBIS), organize classroom supports for preventing, teaching, and responding to students' social, emotional, and behavioral (SEB) needs across the continuum. In classrooms, each educator implements, differentiates, and intensifies critical evidence-based and contextually-relevant SEB practices to meet the needs of all learners. This practice guide emphasizes four critical components of effective SEB support: (1) Prevent SEB challenges by setting students up for success; (2) Teach critical SEB skills; (3) Respond in ways that encourage SEB skills and decrease repeated SEB challenges; and (4) Decide whether to maintain or adjust (e.g., intensify, adapt, or fade) support based on data. It then details a three-tiered continuum of support in which these practices are organized.