In this chapter, the authors provide an introspective account of how teachers in mainstream classrooms can use questioning to more effectively differentiate literacy instruction for English learners across subject areas. The authors offer a rationale for constructively responsive questioning and share tools and strategies for adapting levels of questioning to students' English proficiency and grade levels with the goal of strengthening instruction and promoting student engagement in learning. [For the complete volume, "What's Hot in Literacy: Exemplar Models of Effective Practice. Literacy Research, Practice and Evaluation. Volume 11," see ED614707.]