This article reviews the scientific literature that depicts the influence of the COVID-19 on higher education. Fourteen studies examined pandemic coronavirus's effect on the human respiratory system and its impact on higher education. Nine studies reviewed related to UNESCO and WHO reports, and thirty studies relating to the staff readiness, teachers' efficiency, and e-learning during the lockdown era of COVID-19. Likewise, sixteen peer-reviewed journal articles relating the effect of e-learning on learners' performance and eight studies reviewed relating to the participants' perception included (e.g., awareness and attitude of learning, skills and competency, practical knowledge, assessment and evaluation, class promotion, and accessibility of education. Finally, five studies are regarding the outcomes addressed satisfactory and in the expected direction. It resulted in fourteen studies in a positive trend regarding the COVID-19 pandemic affecting learning. Seven studies reviewed the reports of UNESCO and WHO, and twenty-five studies examined the perception of staff readiness found positive. Twelve studies found the positive in the direction of synchronous and asynchronous e-learning; four studies found that participants have a positive response towards online learning, and the outcomes of three investigations found in the expected direction.