Over the next two years, public education faces a critical moment created by the federal Every Student Succeeds Act requiring states and school districts to identify underperforming schools and create evidence-based plans to improve learning experiences and academic performance of all students. This report recommends key strategies for ensuring that science of adolescent learning principles move from established research findings to actual implementation in these schools through coordinated efforts among researchers, practitioners, and policymakers. In addition to examining why now is a moment of significant opportunity and challenge in education, the report, "Synapses, Students, and Synergies: Applying the Science of Adolescent Learning to Policy and Practice," reviews why adolescence is a critical period of development. It also highlights how organizations, including All4Ed, are making connections between researchers, practitioners, and policymakers to ensure that research on the science of adolescent learning (SAL) informs practice and policy.