Adolescence offers an opportunity for increased learning, but it also is a period of heightened stress due to the many biological and social changes students face. These various stressors can both directly and indirectly disrupt learning processes in still-developing adolescent brains. This Alliance for Excellent Education report underscores the importance of culture, experiences, and environments during this period of life and explains why adolescents need to learn in safe, supportive, and culturally responsive environments. The report also offers recommendations to help educators, policymakers, and parents as they engage, motivate, and prepare middle and high school students for future success.